Sourcing Success: Your Practical Guide to China Supplier Wholesale Berberine Hydrochloride

By qualityherb 24-02-2026 5

The global demand for Berberine Hydrochloride, the bitter yellow alkaloid renowned for its diverse biological activities, has seen a significant uptick. From its traditional use in digestive health to its modern application in advanced supplement formulations, this active pharmaceutical ingredient (API) remains a staple in the health and wellness industry . For businesses looking to purchase this compound in bulk, China remains the dominant force in production and supply.

If you are considering a China supplier wholesale Berberine Hydrochloride for your next shipment, navigating the landscape requires more than just an Alibaba search. It demands an understanding of the market, the product specifications, and the credibility of the manufacturers. Here is a practical look at what the current sourcing environment entails.

Understanding the Product and Its Purity

Before diving into supplier lists, it is crucial to know exactly what you are buying. Berberine Hydrochloride (CAS 633-65-8) is typically derived from plants like Coptis chinensis (golden thread) or Phellodendron amurense (Amur cork tree) . When sourcing wholesale, you will encounter various purity grades, which directly impact the price and application.

Most suppliers in China offer material ranging from 97% to 99% purity as standard for pharmaceutical and supplement use . For instance, companies like Sichuan Yuxin Pharmaceutical highlight their product as a "Natural Extract" with an assay greater than 97% . However, you may also find specialized variations, such as the 70% liposomal Berberine Hydrochloride offered by companies like Hubei Sanxin Pharmaceutical Technology, which is designed for enhanced bioavailability in food and supplement applications .

It is also worth noting that pricing is heavily tied to these purity levels. A quick scan of supplier listings shows significant variance. You might see prices ranging from ¥450 to ¥500 per kilogram for high-volume orders of 98% material, while premium, specialized grades or smaller quantities can command much higher rates . A 99% pharmaceutical-grade product might be listed around ¥1700/kg, reflecting its higher purity and quality control standards .

Key Players in the Market

The Chinese supplier base for Berberine Hydrochloride is diverse, ranging from large-scale pharmaceutical API manufacturers to specialized biotech extraction companies. Here are a few examples of active suppliers in the market:

Sichuan Yuxin Pharmaceutical Co., Ltd. stands out as an established player with over 20 years in the industry. They hold multiple certifications including GMP, FDA, Kosher, and Halal, which is a strong indicator of their commitment to international quality standards .

Xi‘an Henrikang Biotech Co., Ltd. represents the robust supplier base in Shaanxi province. They offer 97% organic Berberine HCl and emphasize their GMP standard workshops and OEM service capabilities, catering to clients who need custom formulations .

On the East Coast, Suzhou Greenway Biotech Co., Ltd. focuses on the cosmetic and personal care application of Berberine Hydrochloride, highlighting its anti-inflammatory properties for functional ingredients .

Additionally, numerous companies based in Hubei—often referred to as the heart of China‘s chemical trading hub—such as Hubei Qianmu Bio-technology and Hubei Hongfuda Biological Technology, act as vital links in the supply chain, offering various grades and packaging options from 25kg drums to larger quantities .

What to Look for in a Wholesale Partner

When evaluating a China supplier wholesale Berberine Hydrochloride, moving beyond the price tag is essential. The most reliable vendors are transparent about their production methods and quality assurance.

Certifications are your first line of defense. Look for suppliers who openly display their ISO, GMP, or FDA certifications. These indicate that the facility adheres to Good Manufacturing Practices .

Third-party testing and documentation are equally important. Reputable suppliers should be able to provide a Certificate of Analysis (COA) with each batch. For example, Ruiwo Phytochem provides a detailed COA on their site, including specs for heavy metals (like Lead ≤1.0ppm), solvent residues, and microbiological counts, ensuring the product is safe for human consumption . This level of detail separates a serious manufacturer from a simple trader.

Supply chain stability is another crucial factor. Companies that control their supply chain—from raw material sourcing to production—are generally more reliable. As noted by Ruiwo, having a "stable supply channel of raw material" ensures volume savings and consistent delivery schedules .

Packaging, Logistics, and MOQs

Understanding logistics is key to a smooth transaction. Berberine Hydrochloride is typically packaged in double plastic bags inside fiber drums, with a standard net weight of 25kg per drum . This packaging is designed to protect the moisture-sensitive yellow powder from degradation.

Minimum Order Quantities (MOQs) vary. While wholesale implies bulk, many Chinese suppliers are flexible. It is common to find MOQs starting at 1 kilogram for high-value samples or small-scale production . For larger, more cost-effective wholesale pricing, suppliers often look for orders of 100kg, 500kg, or even 1000kg .

Shipping methods typically depend on order volume:

Express (3-4 days): Suitable for under 50kg, offering door-to-door service .

Air Freight (4-5 days): Ideal for 50kg to 200kg, balancing speed and cost .

Sea Freight (15-45 days): The most economical choice for orders exceeding 500kg .

Final Thoughts

The market for Berberine Hydrochloride from China is mature, competitive, and full of opportunity. Whether you need high-purity API for pharmaceutical blending or specialized extracts for nutraceuticals, the manufacturing ecosystem in China has a supplier to match your needs. By focusing on certified manufacturers who provide transparent documentation and clear communication, you can secure a high-quality product that meets your specifications and keeps your supply chain running efficiently. Always request a sample and verify the COA before committing to a large wholesale purchase.